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Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks

11 Feb 2019

Abstract excerpt

Somatic mutations have been identified in aldosterone-producing adenomas (APAs) in genes that include KCNJ5, ATP1A1, ATP2B3, and CACNA1D. Based on independent studies, there appears to be racial differences in the prevalence of somatic KCNJ5 mutations, particularly between East Asians and Europeans. Despite the high cardiovascular disease mortality of blacks, there have been no studies focusing on somatic...

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PMID: 30739536
DOI: 10.1161/hypertensionaha.118.12070

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