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Article

Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes.

Neuron - 18 Mar 2015

Huang Brenda, Wei WenJie, Wang Guohao, Gaertig Marta A, Feng Yue, Wang Wei, Li Xiao-Jiang, Li Shihua

Abstract excerpt

Growing evidence indicates that non-neuronal mutant huntingtin toxicity plays an important role in Huntington's disease (HD); however, whether and how mutant huntingtin affects oligodendrocytes, which are vitally important for neural function and axonal integrity, remains unclear. We first verified the presence of mutant huntingtin in oligodendrocytes in HD140Q knockin mice. We then established transgenic mice...

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Identifiers

PMID: 25789755
DOI: 10.1016/j.neuron.2015.02.026
PMCID: PMC4366619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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