Article
Sex differences in the independent and combined effects of genomic and exposomic risks for schizophrenia on distressing psychotic experiences: insights from the ABCD study.
Archives of women's mental health - 6 Jan 2026
Prachason Thanavadee, Arias-Magnasco Angelo, Lin Bochao Danae, van Os Jim, Rutten Bart P F, Pries Lotta-Katrin, Guloksuz Sinan
Abstract excerpt
PURPOSE: To investigate sex-dependent effects of polygenic risk (PRS-SCZ) and exposome score (ES-SCZ) for schizophrenia, both independently and jointly, on distressing psychotic experiences (PEs) in early adolescents. METHOD: Baseline to 3-year follow-up data of the Adolescent Brain and Cognitive Development Study (ABCD) were used. PRS-SCZ and ES-SCZ were calculated to assess cumulative genetic and environmental...
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