Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia.

doi:10.1001/jamapsychiatry.2020.2304

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia.

JAMA psychiatry - 1 Dec 2020

Pries Lotta-Katrin, van Os Jim, Ten Have Margreet, de Graaf Ron, van Dorsselaer Saskia, Bak Maarten, Lin Bochao D, van Eijk Kristel R, Kenis Gunter, Richards Alexander, O'Donovan Michael C, Luykx Jurjen J, Rutten Bart P F, Guloksuz Sinan

Abstract excerpt

Importance: Both adulthood stressful life events (SLEs) and liability for schizophrenia have been associated with poor mental and physical health in the general population, but their interaction remains to be elucidated to improve population-based health outcomes. Objective: To test whether recent SLEs interact with genetic and environmental liability for schizophrenia in models of mental and physical health....

Topics

Adult
Case-Control Studies
Causality
Female
Genetic Predisposition to Disease
Health Status
Health Surveys
Humans
Incidence
Life Change Events

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Longitudinal Studies

Male

Mental Health

Middle Aged

Netherlands

Prospective Studies

Schizophrenia

Stress, Psychological

Source

Open in PubMed Open full text

Identifiers

PMID: 32805017
DOI: 10.1001/jamapsychiatry.2020.2304
PMCID: PMC7711318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia.PMID 32805017Read ↗

Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population.Semantic proximity Read ↗

Sex differences in the independent and combined effects of genomic and exposomic risks for schizophrenia on distressing psychotic experiences: insights from the ABCD study.Semantic proximity Read ↗

Estimating the heritability of reporting stressful life events captured by common genetic variants.Semantic proximity Read ↗

Association between genetic liability to physical health conditions and comorbidities in individuals with severe mental illness: an analysis of two cross-sectional observational studies in the UK.Semantic proximity Read ↗

Nongenetic Factors Associated With Psychotic Experiences Among UK Biobank Participants: Exposome-Wide Analysis and Mendelian Randomization Analysis.Semantic proximity Read ↗

Modifiable risk factors and risk of schizophrenia and bipolar disorder across severities of genetic risk.Semantic proximity Read ↗

Association between stressful life events and psychotic experiences in adolescence: Evidence for gene–environment correlationsSemantic proximity Read ↗

Household income does not affect the pleiotropy of schizophrenia genetic liability with mental and physical health outcomesSemantic proximity Read ↗

Do Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health?Semantic proximity Read ↗

Associations of polygenic risk score, environmental factors, and their interactions with the risk of schizophrenia spectrum disorders.Semantic proximity Read ↗

Polygenic risk scores for schizophrenia and major depression are associated with socio-economic indicators of adversity in two British community samples.Semantic proximity Read ↗

Polygenic Resilience Scores are Associated with Lower Penetrance of Schizophrenia Risk Genes, Protection Against Psychiatric and Medical Disorders, and Enhanced Mental Well-Being and CognitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.