Article

Deep grey matter volume loss drives disability worsening in multiple sclerosis

2017-08-29

Abstract excerpt

<h4>Objective</h4> Grey matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS. <h4>Methods</h4> We analysed 3,604 brain high-resolution T1-weighted MRI scans from 1,417 participants: 1,214 MS patients (253 clinically-isolated syndrome[CIS], 708 relapsingremitting[RR...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 88f3d867-d044-5971-889f-6ef7ae1e9244
DOI: 10.1101/182006

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deep grey matter volume loss drives disability worsening in multiple sclerosisDOI 10.1101/182006Read

Progression of regional grey matter atrophy in multiple sclerosisSemantic proximity Read

Association of Gray Matter Atrophy Patterns With Clinical Phenotype and Progression in Multiple Sclerosis.Semantic proximity Read

Progression of regional atrophy in the left hemisphere contributes to clinical and cognitive deterioration in multiple sclerosis: A 5-year study.Semantic proximity Read

Longitudinal cortical thinning progression differs across multiple sclerosis phenotypes and is clinically relevant: A multicentre study.Semantic proximity Read

Normative Modelling of Brain Volume for Diagnostic and Prognostic Stratification in Multiple SclerosisSemantic proximity Read

The Role of Network Connectivity and Transcriptomic Vulnerability in Shaping Grey Matter Atrophy in Multiple SclerosisSemantic proximity Read

Molecular mechanisms associated with multiple sclerosis progression, severity and phenotypeSemantic proximity Read

The sequence of structural, functional and cognitive changes in multiple sclerosisSemantic proximity Read

Brain age gap correlates with DTI-derived microstructural abnormalities in multiple sclerosisSemantic proximity Read

Characterizing 1-year development of cervical cord atrophy across different MS phenotypes: A voxel-wise, multicentre analysis.Semantic proximity Read

Choroid Plexus Enlargement in Secondary Progressive MS: phenotype comparisonSemantic proximity Read

MS Atlas - A molecular map of brain lesion stages in progressive multiple sclerosisSemantic proximity Read