Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neo-Cysteine Molecular Glues for Targeting Mutated SMAD4 Protein.

Angewandte Chemie (International ed. in English) - 27 Mar 2026

Kumari Pooja, Oum Yoon Hyeun, Miller Eric J, Qui Min, Du Yuhong, Mou Hongmei, Singh Rakesh, Fu Haian, Mo Xiulei

Abstract excerpt

Neo-protein-protein interactions (neoPPIs), directed by genetic mutation-encoded neo-amino acid residues, represent a promising class of precision medicine targets. Small molecules can mimic genetic mutational effects, creating neo-surfaces and acting as molecular glues to mediate neoPPIs and reprogram biological circuitry. This convergence of genomic alterations and chemical interventions highlights a strategy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cysteine
Share to SMAD3 gene
Share to SMAD4 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Smad4 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 41479207
DOI: 10.1002/anie.202512791
PMCID: PMC13034727

Genes

SMAD4
SMAD3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neo-Cysteine Molecular Glues for Targeting Mutated SMAD4 Protein.PMID 41479207Read ↗

Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate RecognitionSemantic proximity Read ↗

GlueFinder: A Data-Driven Framework for the Rational Discovery of Molecular GluesSemantic proximity Read ↗

Cross‐Linking Profiling of Molecular Glue Degrader‐Induced E3 Ligase Interactome to Expand Target SpaceSemantic proximity Read ↗

Systematic discovery of mutation-directed neo-protein-protein interactions in cancerSemantic proximity Read ↗

Assigning functionality to cysteines by base editing of cancer dependency genesSemantic proximity Read ↗

Taming Oncogenic Signaling at Protein Interfaces: Challenges and Opportunities.Semantic proximity Read ↗

Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health.Semantic proximity Read ↗

Molecular surface mimicry enables CRBN to target G3BP2 for degradationSemantic proximity Read ↗

Mechanistic Mutational Scanning to Uncover the Secret Life of Proteins.Semantic proximity Read ↗

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.Semantic proximity Read ↗

A complete map of specificity encoding enables reprogramming of a protein interactionSemantic proximity Read ↗

Protocol to discover actionable cancer vulnerabilities enabled by neomorph protein-protein interactions with the AVERON Notebook.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.