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Article

A two-sample Mendelian randomization study and mediation analysis exploring the link between cathepsins and epilepsy.

Epilepsia open - 1 Feb 2026

Sun Huaiyu, Ma Di, Zhang Wuqiong, Hou Shuai, Chen Zhiqing, Li Xuewei, Meng Hongmei, Zhang Daguang

Abstract excerpt

OBJECTIVE: This study aims to investigate the causal relationship between cathepsins and epilepsy, using Mendelian randomization (MR) and mediation analysis. METHODS: Publicly accessible summary statistics on epilepsy were obtained from FinnGen and the International League Against Epilepsy Consortium. Cathepsin genome-wide association data were provided by the IEU OpenGWAS. To evaluate the causal relationship...

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Identifiers

PMID: 41476372
DOI: 10.1002/epi4.70056
PMCID: PMC12903826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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