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Article

Unveiling the role of cathepsins in depression: a Mendelian randomization study.

Postgraduate medical journal - 13 Feb 2026

Zhuo Guifeng, Chen Wei, Xu Fengsheng, Zhu Xiaomin, Zhang Jinzhi, Su Mingyang, Fu Yulan, Chen Xiangyi, Wu Lin

Abstract excerpt

OBJECTIVE: Depression is a prevalent psychological disorder involving complex pathogenesis mechanisms. Cathepsins may play a significant role in the pathogenesis of depression, yet the exact impact of cathepsins on the risk of developing depression remains unclear. The objective of this research was to examine the cause-and-effect link between cathepsins and the susceptibility to depression through the...

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PMID: 40887099
DOI: 10.1093/postmj/qgaf104

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