Article
Roles of cerebrospinal fluid metabolites in mediating the relationship between cathepsins and narcolepsy type 1: A comprehensive Mendelian randomization analysis.
Progress in neuro-psychopharmacology & biological psychiatry - 20 Mar 2025
Wu Yanjuan, Gan Qiming, Su Xiaofen, Ding Yutong, Liu Quanzhen, Wang Jingcun, Zhang Yuting, Zhang Nuofu, Wu Kang
Abstract excerpt
INTRODUCTION: To investigate the potential causal relationship between cathepsins and Narcolepsy Type 1 (NT1), along with the mediating influence of cerebrospinal fluid metabolites. METHOD: We performed a comprehensive Mendelian randomization (MR) analysis using genome-wide association studies (GWAS) data. Data on nine plasma cathepsins and 338 cerebrospinal fluid metabolites were sourced from the IEU OpenGWAS...
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