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Article

Insight into the structural flexibility and function of Mycobacterium tuberculosis isocitrate lyase.

Biochimie - 1 Mar 2015

Shukla Harish, Kumar Vikash, Singh Amit Kumar, Singh Neha, Kashif Md, Siddiqi Mohammad Imran, Yasoda Krishnan Manju, Sohail Akhtar Md

Abstract excerpt

Isocitrate lyase (ICL), is a key enzyme of the glyoxylate shunt crucial for the survival of Mycobacterium tuberculosis (Mtb) in macrophages during persistent infection. MtbICL catalyses the first step of this carbon anaplerosis cycle and is considered as a potential anti-tubercular drug target. The MtbICL is a tetramer with 222 symmetry, and each subunit of the enzymeis composed of 14 α-helices and 14 β-strands....

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Identifiers

PMID: 25576828
DOI: 10.1016/j.biochi.2014.12.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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