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Article

Polarity effects, resistance, and probiotic enhancement of intoxication of Salmonella enterica fraB mutants in murine models.

PloS one - 1 Jan 2025

Sabag-Daigle Anice, Boulanger Erin F, Baniasad Maryam, Kim Yongseok, Moore Madalyn, Hogue Bailyn, Schwieters Andrew, Gopalan Venkat, Wysocki Vicki, Ahmer Brian M M

Abstract excerpt

FraB is a deglycase in a metabolic pathway that allows Salmonella to utilize fructose-asparagine (F-Asn). Some fraB mutants are sensitive to F-Asn due to the accumulation of 6-phosphofructose-aspartate (6-P-F-Asp), a toxic intermediate in this pathway. We determined that different alleles of fraB cause different amounts of 6-P-F-Asp-mediated toxicity due to effects on the expression of the downstream gene, fraD,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41474808
DOI: 10.1371/journal.pone.0339602
PMCID: PMC12755824

Genes

SPI1

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