Article
Contribution of Asparagine Catabolism to Salmonella Virulence.
Infection and immunity - 1 Feb 2017
McLaughlin Patrick A, McClelland Michael, Yang Hee-Jeong, Porwollik Steffen, Bogomolnaya Lydia, Chen Juei-Suei, Andrews-Polymenis Helene, van der Velden Adrianus W M
Abstract excerpt
Salmonellae are pathogenic bacteria that cause significant morbidity and mortality in humans worldwide. Salmonellae establish infection and avoid clearance by the immune system by mechanisms that are not well understood. We previously showed that l-asparaginase II produced by Salmonella enterica serovar Typhimurium (S Typhimurium) inhibits T cell responses and mediates virulence. In addition, we previously showed...
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