Article
Infection of mice by the enteroaggregative E. coli strain 042 and two mutant derivatives overexpressing virulence factors: impact on disease markers, gut microbiota and concentration of SCFAs in feces.
Scientific reports - 23 Jul 2024
Bernabeu M, Prieto A, Salguero D, Miró L, Cabrera-Rubio R, Collado M C, Hüttener M, Pérez-Bosque A, Juárez A
Abstract excerpt
Several pathogenic Escherichia coli strains cause diarrhea. Enteroaggregative E. coli (EAEC) strains are one of the diarrheagenic pathotypes. EAEC cells form a "stacked-brick" arrangement over the intestinal epithelial cells. EAEC isolates express, among other virulence determinants, the AggR transcriptional activator and the aggregative adherence fimbriae (AAF). Overexpression of the aggR gene results in...
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