Article
Isolation and Analysis of Suppressor Mutations in Tumor-Targeted msbB Salmonella.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016
Low K Brooks, Murray Sean R, Pawelek John, Bermudes David
Abstract excerpt
Tumor-targeted Salmonella offers a promising approach to the delivery of therapeutics for the treatment of cancer. The Salmonella strains used, however, must be stably attenuated in order to provide sufficient safety for administration. Approaches to the generation of attenuated Salmonella strains have included deletion of the msbB gene that is responsible for addition of the terminal myristol group to lipid A....
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