Back to search

Article

A Tale of Twins: The Distinct Roles of Intracellular and Extracellular Formate in Regulating Flagellar and Pathogenicity Island-1 Genes in <i>Salmonella</i> Typhimurium

2024-01-31

Abstract excerpt

Host-derived short-chain fatty acids (SCFAs) are extensively being studied for their role in the virulence and pathogenesis of Salmonella Typhimurium (STM). Formate, an SCFA present in the ileum, functions as a signalling molecule to enhance STM invasion. However, the role of intracellular formate in Salmonella virulence remains poorly understood. To investigate this, we generated knockouts of pflB (pyruvate-fo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
10b7fe29-e273-54de-9a4b-994eaa01d75a
DOI
10.1101/2024.01.30.577997
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Tale of Twins: The Distinct Roles of Intracellular and Extracellular Formate in Regulating Flagellar and Pathogenicity Island-1 Genes in <i>Salmonella</i> TyphimuriumDOI 10.1101/2024.01.30.577997
The quorum-sensing lexicon of <i>Salmonella</i> ameliorates acid stress in the host by a non-canonical mechanismSemantic proximity
The intestinal fatty acid propionate inhibits <i><scp>S</scp>almonella</i> invasion through the post‐translational control of <scp><scp>HilD</scp></scp>Semantic proximity
Intracellular <i>Salmonella</i> Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to Intracellular <i>S</i> . TyphimuriumSemantic proximity
Screening and Identification of Key Genes for the Survival and Multiplication of Salmonella typhimurium in the HostSemantic proximity
Site-specific acylation of a bacterial virulence regulator attenuates infection.Semantic proximity
Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to intracellular S. TyphimuriumSemantic proximity
Niche-specific profiling reveals transcriptional adaptations required for the cytosolic lifestyle of <i>Salmonella enterica</i>Semantic proximity
Genetic determinants in <i>Salmonella enterica</i> serotype Typhimurium required for overcoming stressors in the host environmentSemantic proximity
The T6SS effector Tldi1 enhances Salmonella enterica serovar Typhimurium virulence by regulating motility and stress adaptationSemantic proximity
Impaired acid stress resistance in <i>Salmonella</i> Typhi Ty2Semantic proximity
SPI-1 virulence gene expression modulates motility of <i>Salmonella</i> Typhimurium in a proton motive force- and adhesins-dependent mannerSemantic proximity
Shigella flexneri utilizes intestinal signals to control its virulenceSemantic proximity
Select a neighboring publication to make it the new centre.