Article
A metabolic intermediate of the fructose-asparagine utilization pathway inhibits growth of a Salmonella fraB mutant.
Scientific reports - 12 Jul 2016
Sabag-Daigle Anice, Blunk Henry M, Sengupta Anindita, Wu Jikang, Bogard Alexander J, Ali Mohamed M, Stahl Christopher, Wysocki Vicki H, Gopalan Venkat, Behrman Edward J, Ahmer Brian M M
Abstract excerpt
Insertions in the Salmonella enterica fra locus, which encodes the fructose-asparagine (F-Asn) utilization pathway, are highly attenuated in mouse models of inflammation (>1000-fold competitive index). Here, we report that F-Asn is bacteriostatic to a fraB mutant (IC50 19 μM), but not to the wild-type or a fra island deletion mutant. We hypothesized that the presence of FraD kinase and absence of FraB deglycase...
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