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Article

Very long O-antigen chains enhance fitness during Salmonella-induced colitis by increasing bile resistance.

PLoS pathogens - 1 Sept 2012

Crawford Robert W, Keestra A Marijke, Winter Sebastian E, Xavier Mariana N, Tsolis Renée M, Tolstikov Vladimir, Bäumler Andreas J

Abstract excerpt

Intestinal inflammation changes the luminal habitat for microbes through mechanisms that have not been fully resolved. We noticed that the FepE regulator of very long O-antigen chain assembly in the enteric pathogen Salmonella enterica serotype Typhimurium (S. Typhimurium) conferred a luminal fitness advantage in the mouse colitis model. However, a fepE mutant was not defective for survival in tissue, resistance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23028318
DOI: 10.1371/journal.ppat.1002918
PMCID: PMC3447750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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