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Article

Functional diversity in GII.4 norovirus entry: HBGA binding and capsid clustering dynamics.

Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2025

Ayyar B Vijayalakshmi, Apostol Carmen V, Dave Janam Jitendra, Kaundal Soni, Kendra Joseph A, Neill Frederick H, Ettayebi Khalil, Maher Sarah, Anish Ramakrishnan, Parra Gabriel I, Larson Göran, Atmar Robert L, Crawford Sue E, Prasad B V Venkataram, Estes Mary K

Abstract excerpt

Human noroviruses (HuNoVs), especially GII.4 strains, are the leading cause of acute viral gastroenteritis worldwide, yet no approved vaccines or antivirals exist. The pandemic GII.4 Sydney 2012 strain enters cells via membrane wounding and clathrin-independent carrier-mediated endocytosis, but it is unclear whether this entry mechanism is conserved across GII.4 variants. We compared early binding and entry of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41032521
DOI: 10.1073/pnas.2517493122
PMCID: PMC12519127

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