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Article

The CCL17-CCR4 Axis Is Critical for Mutant STAT6-Mediated Microenvironmental Remodeling and Therapeutic Resistance in Relapsed/Refractory Diffuse Large B-Cell Lymphoma.

Cancer immunology research - 4 Mar 2026

Abraham Madelyn J, Guilbert Cynthia, Gagnon Natascha, Gonçalves Christophe, Benoit Alexandre, Tran Kelly, Hiltebrand Owen, Rys Ryan N, Preston Samuel E J, Morin Ryan D, Miller Wilson H, Johnson Nathalie A, Del Rincon Sonia V, Mann Koren K

Abstract excerpt

Relapsed and refractory diffuse large B-cell lymphoma (rrDLBCL) presents a significant challenge in hematology-oncology, with approximately 30% to 40% of patients with DLBCL experiencing relapse or resistance to treatment. This underscores the urgent need to better understand the molecular mechanisms governing therapeutic resistance. Signal transducer and activator of transcription 6 (STAT6) has been previously...

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Topics

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Share to CD4-Positive T-Lymphocytes
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Drug Resistance, Neoplasm

Share to Lymphoma, Large B-Cell, Diffuse

Share to STAT6 Transcription Factor

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 41460722
DOI: 10.1158/2326-6066.CIR-25-0583
PMCID: PMC13012241

Genes

CD4
CCR4
STAT6
CCL17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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