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Article

Gain-of-function CCR4 mutations in adult T cell leukemia/lymphoma.

The Journal of experimental medicine - 15 Dec 2014

Nakagawa Masao, Schmitz Roland, Xiao Wenming, Goldman Carolyn K, Xu Weihong, Yang Yandan, Yu Xin, Waldmann Thomas A, Staudt Louis M

Abstract excerpt

Adult T cell leukemia/lymphoma (ATLL) is an aggressive malignancy caused by human T cell lymphotropic virus type-I (HTLV-I) without curative treatment at present. To illuminate the pathogenesis of ATLL we performed whole transcriptome sequencing of purified ATLL patient samples and discovered rec...

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Source

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Identifiers

PMID: 25488980
DOI: 10.1084/jem.20140987
PMCID: PMC4267233

Genes

CCR4
CCL22
CCL17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25488980-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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