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Atypical chemokine receptors in cancer

23 Jan 2024

Abstract excerpt

Atypical chemokine receptors (ACKRs) are a group of seven-transmembrane spanning serpentine receptors that are structurally homologous to classical G-protein-coupled receptors and bind cognate chemokines with high affinities but do not signal via G-proteins or mediate cell migration. However, ACKRs efficiently modify the availability and function of chemokines in defined microanatomical environments, can signal...

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PMID: 38266462
DOI: 10.1016/j.cyto.2024.156504

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