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Protocol: Estimating cross-ancestry local genetic correlation using Logica.

STAR protocols - 20 Mar 2026

Gao Boran, Li Zheng, Zhou Xiang

Abstract excerpt

Here, we present a reproducible protocol for estimating cross-ancestry local genetic correlation using Logica, a likelihood-based framework that employs summary statistics from genome-wide association studies (GWASs) and ancestry-specific linkage disequilibrium (LD). We describe steps for estimating locus-level heritability and cross-ancestry genetic correlation and outlining required inputs. We then detail...

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PMID: 41447520
DOI: 10.1016/j.xpro.2025.104299
PMCID: PMC12799944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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