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Article

Clinical Function Assignment of NAT2 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel.

Clinical pharmacology and therapeutics - 1 Oct 2026

Tibben Bailey M, Hein David W, Whirl-Carrillo Michelle, Gaedigk Andrea, Eadon Michael T, Minchin Rodney F, Boukouvala Sotiria, Santos Adalberto Rezende, Donnelly Roseann S, Agúndez José A G, Caudle Kelly E

Abstract excerpt

NAT2 encodes arylamine N-acetyltransferase 2, a key enzyme in the phase II metabolism of arylamines and arylhydrazines. NAT2 is highly polymorphic, resulting in variable distributions of rapid and poor metabolizers across global populations. Here, we detail the process undertaken by the Clinical Pharmacogenetics Implementation Consortium (CPIC) NAT2 Pharmacogene Curation Expert Panel (PCEP) to assign clinical...

Read the complete abstract on PubMed

Topics

Arylamine N-Acetyltransferase
Humans
Pharmacogenetics
Alleles
Phenotype

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Source

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Identifiers

PMID: 42538601
DOI: 10.1002/cpt.70420
PMCID: PMC13427928

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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