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Article

Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy.

Molecular psychiatry - 1 Feb 2024

Belaidi Abdel Ali, Masaldan Shashank, Southon Adam, Kalinowski Pawel, Acevedo Karla, Appukuttan Ambili T, Portbury Stuart, Lei Peng, Agarwal Puja, Leurgans Sue E, Schneider Julie, Conrad Marcus, Bush Ashley I, Ayton Scott

Abstract excerpt

Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer's disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is characteristic of AD CSF, and predicts cognitive decline. The mechanisms underlying the genotype and apoE level risks are uncertain. Recent fluid and imaging biomarker studies have revealed an unexpected link between apoE and brain iron,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35484240
DOI: 10.1038/s41380-022-01568-w
PMCID: PMC9757994

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