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Article

Multi-omics profiling uncovers candidate genes for the treatment of graves' disease.

Immunopharmacology and immunotoxicology - 1 Feb 2026

Gao Jian, Zheng Zifang, Zhang Guolie

Abstract excerpt

BACKGROUND: This Summary-data-based Mendelian randomization (SMR) study investigates the genetic basis of Graves' disease (GD) using a multi-omics approach to elucidate biological mechanisms and identify therapeutic candidates. METHODS: SMR and Bayesian colocalization analyzed GD associations with methylation (mQTL), expression (eQTL), and protein quantitative trait loci (pQTL) using FinnGen as the discovery...

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PMID: 41424108
DOI: 10.1080/08923973.2025.2603439

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AIF1
AGER

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