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Article

Large-Scaled Proteomics Analysis for Glaucoma: Integrated Genetics, Multi-Omics, UK Biobank and Therapeutic Analysis.

Investigative ophthalmology & visual science - 2 Feb 2026

Xu Jianming, Gao Yuelan, Yu Jun, Xu Zihe, Zhang Yuzhou, Pang Chi Pui, Tham Clement C, Yam Jason C, Chen Li Jia

Abstract excerpt

Purpose: To identify plasma proteins associated with glaucoma and assess the translational potential of key proteins as both biomarkers and therapeutic targets. Methods: Genome-wide association study data were obtained from the UK Biobank Pharma Proteomics Project, FinnGen, and the Million Veteran Program. We used a four-stage analytical framework: Stage 1 applied Mendelian randomization and Bayesian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41626871
DOI: 10.1167/iovs.67.2.4
PMCID: PMC12889177

Genes

COL24A1
EFEMP1
AXIN1
AZI2
CSNK1D
EBAG9
KAZALD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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