Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prioritization of potential drug targets in ovarian-related diseases: Mendelian randomization and colocalization analyses.

F&S science - 1 May 2025

Hong Yanggang

Abstract excerpt

OBJECTIVE: To identify key genes and potential drug targets for ovarian-related diseases through genome-wide Mendelian randomization (MR) and colocalization analyses. DESIGN: We conducted a comprehensive two-sample MR analysis to estimate the causal effects of blood expression quantitative trait loci (eQTLs) on ovarian-related diseases, followed by colocalization analyses to verify the robustness of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ABCB4 gene
Share to CTNNB1 gene
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Ovarian Diseases

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Identifiers

PMID: 39988236
DOI: 10.1016/j.xfss.2025.02.003

Genes

ABCB4
CD163L1
CTNNB1
F12
GNA15
MTAP
NRM
PPP3CA
PTPN7
SLC6A9
ZNF66

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prioritization of potential drug targets in ovarian-related diseases: Mendelian randomization and colocalization analyses.PMID 39988236Read ↗

Therapeutic targets for endometriosis: Genome-wide Mendelian randomization and colocalization analyses.Semantic proximity Read ↗

Identification of breast cancer susceptibility genes via trans-ethnic Mendelian randomization and colocalization analyses.Semantic proximity Read ↗

The role of immune cell signatures in the pathogenesis of ovarian-related diseases: a causal inference based on Mendelian randomizationSemantic proximity Read ↗

Shared Genetic Architecture and Pleiotropic Loci Linking Endometriosis and Inflammatory Bowel Disease: An Integrative GWAS, Colocalization, and Mendelian Randomization Study.Semantic proximity Read ↗

Mendelian randomization Identifies RSPO3 in Serum as a Potential Target for EndometriosisSemantic proximity Read ↗

Integrative multi-omics analysis of druggable genes for therapeutic target identification in polycystic ovary syndrome.Semantic proximity Read ↗

From proteome to pathogenesis: investigating polycystic ovary syndrome with Mendelian randomization analysis.Semantic proximity Read ↗

Colocalization highlights genes in hypothalamic–pituitary–gonadal axis as potentially mediating polycystic ovary syndrome riskSemantic proximity Read ↗

Identifying Potential Drug Targets for the Treatment of Ulcerative Colitis Using Mendelian Randomization Combined with Co-localization AnalysisSemantic proximity Read ↗

The Causal Relationship Between the Levels of 91 Circulating Inflammatory Proteins and Ovarian-Related Diseases: A Bidirectional Mendelian Randomization Study.Semantic proximity Read ↗

Colocalization analysis of polycystic ovary syndrome to identify potential disease-mediating genes and proteinsSemantic proximity Read ↗

Finding Potential Drug Targets for Pre-Eclampsia Using Mendelian Randomisation and Colocalisation Analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.