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Article

Immune Cell-specific Genetic Regulation in Graves' Disease: An Integrative Mendelian Randomization Study.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Cui Shixian, Liu Qingyang, Gao Tianshu

Abstract excerpt

INTRODUCTION: Graves' disease (GD) is an autoimmune form of hyperthyroidism. We integrated GD GWAS summary statistics with immune-cell eQTLs to prioritize cell-type-specific genes with potential relevance to GD susceptibility. METHODS: We analyzed European-ancestry GD GWAS summary statistics from FinnGen Release 12 together with cis-eQTLs from 14 peripheral immune-cell subsets in the OneK1K single-cell resource...

Read the complete abstract on PubMed

Topics

Graves Disease
Humans
Genome-Wide Association Study
Genetic Predisposition to Disease
Quantitative Trait Loci
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Gene Expression Regulation

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 42333856
DOI: 10.2174/0118715303437190260604115140
PMCID: PMC13629157

Genes

ARID5B
CD4
FCRL3
PRSS16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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