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Article

Epidemiological characterization of chromosome-mediated colistin resistance in hypervirulent carbapenem-resistant Klebsiella pneumoniae.

BMC microbiology - 15 Dec 2025

Xiao Yanghua, Zhang Jingwen, Nie Feng, Li Keyi, Tao Xingyu, Xiang Tianxin, Li Ping

Abstract excerpt

BACKGROUND: Hypervirulent and carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) poses a major clinical threat. Colistin is a last-resort agent against hv-CRKP, yet resistance driven by chromosomal mutations remains poorly characterized in its prevalence and functional impact. METHODS: From 2020 to 2023, 239 non-duplicate clinical hv-CRKP isolates were collected from a tertiary hospital in China. Isolates were...

Topics

Colistin
Anti-Bacterial Agents
Klebsiella pneumoniae
Klebsiella Infections
Microbial Sensitivity Tests
Bacterial Proteins
Animals
Drug Resistance, Bacterial
Humans
Carbapenems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Chromosomes, Bacterial

China

Mutation

Virulence

Multilocus Sequence Typing

Whole Genome Sequencing

Carbapenem-Resistant Enterobacteriaceae

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 41398649
DOI: 10.1186/s12866-025-04615-y
PMCID: PMC12849141

Genes

HAMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41398649-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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