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Article

TERT expression is associated with metastasis from thin primaries, exhausted CD4+ T cells in melanoma and with DNA repair across cancer entities.

PloS one - 1 Jan 2023

Kuhn Christina Katharina, Meister Jaroslawna, Kreft Sophia, Stiller Mathias, Puppel Sven-Holger, Zaremba Anne, Scheffler Björn, Ullrich Vivien, Schöneberg Torsten, Schadendorf Dirk, Horn Susanne

Abstract excerpt

Telomerase reverse transcriptase (TERT) promoter mutations occur frequently in cancer, have been associated with increased TERT expression and cell proliferation, and could potentially influence therapeutic regimens for melanoma. As the role of TERT expression in malignant melanoma and the non-canonical functions of TERT remain understudied, we aimed to extend the current knowledge on the impact of TERT promoter...

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Share to CD4-Positive T-Lymphocytes
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma

Share to Mutation

Share to Promoter Regions, Genetic

Share to Skin Neoplasms

Share to Telomerase

Source

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Identifiers

PMID: 37418389
DOI: 10.1371/journal.pone.0281487
PMCID: PMC10328343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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