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Highly Specific Detection of miRNA Mutants Using a Combined Analysis of Functionalized Micropipette and Hybridization Free Energy.

Analytical chemistry - 13 Jan 2026

Zhang Yu, Wang Shisheng, Dong Jiacheng, Yang Zhongyu, Rao Yanhua, Deng Chao, Ding Yihong, Wang Yajun, Liu Nannan, Xia Fan

Abstract excerpt

Base mutations (mismatches, insertions, or deletions) in microRNAs (miRNAs) are frequently associated with diseases including as cancer, where they significantly alter miRNA structure and function. However, the accurately detection of low-abundance mutants amid highly similar sequences remains a major challenge. In this study, we developed a sensing strategy based on the ionic current and hybridization free...

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PMID: 41412170
DOI: 10.1021/acs.analchem.5c06980

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