Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MET alterations are enriched in lung adenocarcinoma brain metastases, defining a distinct biologic subtype.

The Journal of clinical investigation - 16 Feb 2026

Burns Timothy F, Dacic Sanja, Chakka Anish, Miller Ethan, Velez Maria A, Somasundaram Ashwin, Bhattacharya Saveri, Gaither-Davis Autumn, Devadassan Princey, Jin Jingxiao, Kumar Vinod, Pennathur Arjun, Xiu Joanne, Oberley Matthew, Glantz Michael J, Aulakh Sonikpreet, Chandran Uma R, Bao Riyue, Tatsuoka Curtis, Stabile Laura P

Abstract excerpt

Non-small cell lung cancer exhibits the highest rates of brain metastases (BMs) among all solid tumors, presenting a major clinical challenge. The development of novel therapeutic strategies targeting BMs is clearly needed. We identified a significant enrichment of MET amplification in lung adenocarcinoma (LUAD) BMs compared with primary LUAD and extracranial metastases in oncogene driver-negative patients. Of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma of Lung
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Gene Amplification

Share to Nuclear Proteins

Share to Proto-Oncogene Proteins c-met

Share to Tumor Microenvironment

Share to Twist-Related Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 41411048
DOI: 10.1172/JCI194708
PMCID: PMC12904726

Genes

MET
TWIST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MET alterations are enriched in lung adenocarcinoma brain metastases, defining a distinct biologic subtype.PMID 41411048Read ↗

Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma.Semantic proximity Read ↗

The Mutation Patterns of MET Gene in Lung Cancer and Brain Tumors: Clinical and Therapeutic Implications.Semantic proximity Read ↗

The METeoric rise of MET in lung cancerSemantic proximity Read ↗

Mutational landscapes of brain metastases across various histological subtypes of lung cancer.Semantic proximity Read ↗

Genes associated with increased brain metastasis risk in non–small cell lung cancer: Comprehensive genomic profiling of 61 resected brain metastases versus primary non–small cell lung cancer (Guangdong Association Study of Thoracic Oncology 1036)Semantic proximity Read ↗

MET alterations in advanced non-small cell lung cancer.Semantic proximity Read ↗

MET alterations and their impact on the future of non-small cell lung cancer (NSCLC) targeted therapies.Semantic proximity Read ↗

Comparative genomic profiling identifies targetable brain metastasis drivers in non-small cell lung cancerSemantic proximity Read ↗

Extensive MET alterations confer clinical response to MET inhibitors in gliomasSemantic proximity Read ↗

Clinicopathologic and Genomic Landscape of Non-Small Cell Lung Cancer Brain Metastases.Semantic proximity Read ↗

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic TargetSemantic proximity Read ↗

Whole-exome sequencing identifies somatic mutations associated with lung cancer metastasis to the brainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.