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MET alterations in advanced non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2023

Sakamoto Mandy, Patil Tejas

Abstract excerpt

Targeting the MET pathway in advanced NSCLC has been of particular interest due to its role as both a primary oncogenic driver and secondary oncogenic driver of acquired resistance. Activation of the MET pathway can occur through several mechanisms, which can complicate the diagnostic and treatment approach. Recently, several MET-directed therapies have been developed with promising results. In this narrative...

Topics

Humans
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Proto-Oncogene Proteins c-met
Protein Kinase Inhibitors
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36924573
DOI: 10.1016/j.lungcan.2023.02.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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