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Article

The Mutation Patterns of MET Gene in Lung Cancer and Brain Tumors: Clinical and Therapeutic Implications.

Cancer medicine - 1 Jan 2026

Zhang Yu, Luo Ningning, Ge Minghui, Zhang Yanxiang, Chen Dongsheng, Li Yongmeng

Abstract excerpt

OBJECTIVES: MET aberrations are capable of triggering oncogenesis through multiple clinical significance genomic alterations. In non-small cell lung cancer, MET exon 14 skipping and MET amplification confer sensitivity to MET tyrosine kinase inhibitors. The MET gene is also one of the druggable genes in high-grade gliomas. However, a systematic comparison of MET variations between lung cancer and brain tumors is...

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Identifiers

PMID: 41521799
DOI: 10.1002/cam4.71532
PMCID: PMC12793781

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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