Article
MET alterations and their impact on the future of non-small cell lung cancer (NSCLC) targeted therapies.
Expert opinion on therapeutic targets - 1 Apr 2021
Lee Matthew, Jain Prantesh, Wang Feng, Ma Patrick C, Borczuk Alain, Halmos Balazs
Abstract excerpt
Introduction: The MET gene and its pathway normally plays a crucial role in cell homeostasis, motility, and apoptosis. However, when the MET gene is altered, there is an imbalance toward cell proliferation and invasion commonly seen in numerous different types of cancers. The heterogeneous group of MET alterations that includes MET amplification, MET exon 14 skipping mutation, and MET fusions has been difficult...
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