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Article

Mendelian randomization and AlphaFold3 analysis suggest putative causal plasma proteins in graves' disease.

Journal of bioinformatics and computational biology - 1 Dec 2025

Deng Bin, Liao Zhanlin, Huang Liangzhi, Chen Ting, Chen Qiao, Zhong Shuai, Huang Zugui

Abstract excerpt

Graves' disease (GD) is a common autoimmune disorder. However, the circulating proteins that causally drive its pathogenesis remain largely unconfirmed by genetic evidence. Identifying such proteins is critical for developing novel therapeutics. Methods: We performed a two-sample Mendelian randomization (MR) analysis using genetic instruments for 4907 plasma proteins and summary statistics from a GD genome-wide...

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Identifiers

PMID: 41403226
DOI: 10.1142/S0219720025500234

Genes

CTSS
CD5L

Variants

rs41271951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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