Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Potential Key Genes for Giant Cell Arteritis Revealed Based on Single-Cell Sequencing and Mendelian Randomization Analysis.

International archives of allergy and immunology - 1 Jan 2026

Cheng Tao, Chen Jiafan, Shan Xinjue, Jia Bochao, Sang Sulin, Wang Yunkai, Wei Yi, Hu Yuanhui

Abstract excerpt

INTRODUCTION: Giant cell arteritis (GCA) is an autoimmune disease affecting medium and large arteries. It varies in presentation and often recurs, potentially leading to blindness and aneurysms. The pathogenesis of GCA is not well understood. This study aimed to identify key genes linked to GCA and explore potential pathogenic mechanisms. METHODS: This study integrated single-cell RNA sequencing, expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GCA gene
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Giant Cell Arteritis

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Single-Cell Analysis

Source

Identifiers

PMID: 40349694
DOI: 10.1159/000546323

Genes

GCA
RCAN3
RPS6
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Potential Key Genes for Giant Cell Arteritis Revealed Based on Single-Cell Sequencing and Mendelian Randomization Analysis.PMID 40349694Read ↗

Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study.Semantic proximity Read ↗

Identification of the VLDLR locus associated with giant cell arteritis and the possible causal role of low-density lipoprotein cholesterol in its pathogenesis.Semantic proximity Read ↗

Polymyalgia rheumatica and giant cell arteritis: A bidirectional Mendelian randomization study.Semantic proximity Read ↗

Genetic component of giant cell arteritis.Semantic proximity Read ↗

A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility.Semantic proximity Read ↗

Cross-Trait Meta-Analysis Reveals a Genetic Link between Inflammation and Aging in Giant Cell Arteritis.Semantic proximity Read ↗

Causal effects of systemic inflammatory proteins on Guillain-Barre Syndrome: insights from genome-wide Mendelian randomization, single-cell RNA sequencing analysis, and network pharmacology.Semantic proximity Read ↗

Genome-wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patientsSemantic proximity Read ↗

Exploring the bidirectional relationships between alzheimer's disease and cerebral small vessel disease: Insights from mendelian randomizationSemantic proximity Read ↗

Genetics of vasculitis.Semantic proximity Read ↗

New insights into the pathogenesis of giant cell arteritis and hopes for the clinic.Semantic proximity Read ↗

Association between Guillain-Barré syndrome and 7 autoimmune diseases: a mendelian randomization study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.