Article

Mendelian Randomization Reveals Causal Pathways Between Plasma Protein Quantitative Trait Loci and Graves’Disease Mediated by Immune Cells

2025-01-03

Abstract excerpt

Graves’ disease (GD) is an autoimmune disorder characterized by hyperthyroidism caused by thyroid-stimulating antibodies (TRAb) activating the thyroid-stimulating hormone receptor (TSHR). Current treatments, including antithyroid drugs, radioactive iodine therapy, and surgery, can control hormone secretion but fail to prevent the immune system’s persistent attacks on the thyroid gland. This highlights the need for...

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Literature Corpus work: 45dbc78b-8c0b-5f3e-8630-8c974b42b6ee
DOI: 10.1101/2025.01.02.25319932

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