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Article

Proteome-Wide Mendelian Randomization Identifies Causal Proteins for Multiple Sclerosis Susceptibility and Severity.

Genes - 16 Jul 2026

Chen Ke, Zou Qin, Yao Yuan

Abstract excerpt

Background: Despite significant advances in identifying genetic risk factors for multiple sclerosis (MS), the causal involvement of circulating proteins in disease development and severity remains largely unexplored. Understanding these protein-mediated pathways could reveal novel therapeutic opportunities for this complex neurological disorder. Methods: We performed a proteome-wide Mendelian randomization study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42510850
DOI: 10.3390/genes17070810
PMCID: PMC13409751

Genes

ALPI
CBR1
IDUA
LYVE1
MANSC1
MXRA8
NID2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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