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Article

A missense variant, rs373863828-A (p.Arg457Gln), of CREBRF and body mass index in Oceanic populations.

Journal of human genetics - 1 Sept 2017

Naka Izumi, Furusawa Takuro, Kimura Ryosuke, Natsuhara Kazumi, Yamauchi Taro, Nakazawa Minato, Ataka Yuji, Ishida Takafumi, Inaoka Tsukasa, Matsumura Yasuhiro, Ohtsuka Ryutaro, Ohashi Jun

Abstract excerpt

It has been suggested that a 'thrifty' genotype hypothesis can account for high prevalence of obesity in the island populations of Oceania. A recent genome-wide association study revealed that a missense variant, rs373863828-A (p.Arg457Gln), of the CREBRF gene (encoding CREB3 regulatory factor) was associated with an excessive increase in body mass index (BMI) in Samoans. In the present study, the association of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amino Acid Substitution
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Share to Genetics, Population
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Share to Mutation, Missense
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Source

Identifiers

PMID: 28405013
DOI: 10.1038/jhg.2017.44

Variants

rs373863828

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

A missense variant, rs373863828-A (p.Arg457Gln), of CREBRF and body mass index in Oceanic populations.PMID 28405013Read ↗

A thrifty variant in CREBRF strongly influences body mass index in Samoans.Semantic proximity Read ↗

Polygenic and single-locus selection on BMI during Polynesian expansion.Semantic proximity Read ↗

Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand.Semantic proximity Read ↗

The missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans.Semantic proximity Read ↗

Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1A is associated with BMI in Tongans.Semantic proximity Read ↗

<i>CREBRF</i> missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesians living in Samoa and Aotearoa New ZealandSemantic proximity Read ↗

CREBRF variant increases obesity risk and protects against diabetes in Samoans.Semantic proximity Read ↗

Discordant association of the <i>CREBRF</i> rs373863828 minor allele with increased body mass index and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa New ZealandSemantic proximity Read ↗

The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body compositionSemantic proximity Read ↗

The Pacific-specific CREBRF rs373863828 allele protects against gestational diabetes mellitus in Māori and Pacific women with obesity.Semantic proximity Read ↗

The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition.Semantic proximity Read ↗

A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants.Semantic proximity Read ↗

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