A thrifty variant in CREBRF strongly influences body mass index in Samoans.

doi:10.1038/ng.3620

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Article

A thrifty variant in CREBRF strongly influences body mass index in Samoans.

Nature genetics - 1 Sept 2016

Minster Ryan L, Hawley Nicola L, Su Chi-Ting, Sun Guangyun, Kershaw Erin E, Cheng Hong, Buhule Olive D, Lin Jerome, Reupena Muagututi'a Sefuiva, Viali Satupa'itea, Tuitele John, Naseri Take, Urban Zsolt, Deka Ranjan, Weeks Daniel E, McGarvey Stephen T

Abstract excerpt

Samoans are a unique founder population with a high prevalence of obesity, making them well suited for identifying new genetic contributors to obesity. We conducted a genome-wide association study (GWAS) in 3,072 Samoans, discovered a variant, rs12513649, strongly associated with body mass index (BMI) (P = 5.3 × 10(-14)), and replicated the association in 2,102 additional Samoans (P = 1.2 × 10(-9)). Targeted...

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Identifiers

PMID: 27455349
DOI: 10.1038/ng.3620
PMCID: PMC5069069

Variants

rs373863828

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A thrifty variant in CREBRF strongly influences body mass index in Samoans.PMID 27455349Read ↗

CREBRF variant increases obesity risk and protects against diabetes in Samoans.Semantic proximity Read ↗

A missense variant, rs373863828-A (p.Arg457Gln), of CREBRF and body mass index in Oceanic populations.Semantic proximity Read ↗

A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants.Semantic proximity Read ↗

The missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans.Semantic proximity Read ↗

Polygenic and single-locus selection on BMI during Polynesian expansion.Semantic proximity Read ↗

Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort.Semantic proximity Read ↗

Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand.Semantic proximity Read ↗

Genomic variants at 20p11 associated with body fat mass in the European population.Semantic proximity Read ↗

Can evidence from genome-wide association studies and positive natural selection surveys be used to evaluate the thrifty gene hypothesis in East Asians?Semantic proximity Read ↗

Characterization of sleep apnea among a sample of adults from SamoaSemantic proximity Read ↗

Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes.Semantic proximity Read ↗

The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body compositionSemantic proximity Read ↗

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