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Priming of rat bone marrow-derived mesenchymal stem cells with curcumin induces an anti-inflammatory M2 phenotype in J774A.1 macrophage cell line.

BMC complementary medicine and therapies - 11 Dec 2025

Daryabor Gholamreza, Kheshtchin Nasim, Hashemi Seyede Zahra, Kahmini Fatemeh Rezaei, Gholijani Nasser

Abstract excerpt

CONTEXT: In recent years, several strategies have been used to enhance mesenchymal stem cells’ (MSCs) immunomodulatory and therapeutic potential. Curcumin (Cur), the main active component of turmeric from the Curcuma longa plant, might improve the effectiveness of MSCs. MATERIALS AND METHODS: Lipopolysaccharide (LPS)-stimulated J774.1 macrophages were treated with either Cur (10, 20, and 40 µM) or Rat bone...

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Anti-Inflammatory Agents
Cell Line
Curcumin
Cytokines
Lipopolysaccharides

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Mesenchymal Stem Cells

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PMID: 41382111
DOI: 10.1186/s12906-025-05207-z
PMCID: PMC12801598

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TNF

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