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Macrophage Polarization Towards M2 Phenotype by Curcuminoids Through NF-κB Pathway Inhibition in Adjuvant-Induced Arthritis.

International immunopharmacology - 1 Jun 2023

Abd-Elhalem Sahar S, Al-Doori Mohamed H, Hassen Marwa T

Abstract excerpt

Macrophage polarization is decisive for homeostasis maintenance and tissue repair. Anti-inflammatory properties of curcumin (CUR) have been demonstrated in several studies. It used in the treatment of bone disorders includingrheumatoid arthritis. The present study aims to explore the potential mechanisms of curcumin on macrophage polarization, expression, activation, and cytokine secretion in adjuvant-induced...

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Arthritis, Experimental
Curcumin
Macrophages
Methotrexate
NF-kappa B

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PMID: 37130441
DOI: 10.1016/j.intimp.2023.110231

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