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Article

Treatment with sitagliptin exacerbates the M2 phenotype in macrophages in vitro.

International immunopharmacology - 3 Jan 2025

Quadros-Pereira Laura, Nery-Neto José Arimatéa de Oliveira, Da Silva Eloisa Martins, Doretto-Silva Lorena, Yariwake Victor Yuji, Câmara Niels Olsen, Andrade-Oliveira Vinicius

Abstract excerpt

Macrophages (MØ) participate in the induction and the control of the host's immune response in homeostasis and during inflammatory diseases. Sitagliptin is a drug that inhibits the enzyme dipeptidyl peptidase 4 (DPP-4) and, therefore, increases the bioavailability of the incretins GIP (Gastric inhibitory polypeptide) and GLP-1 (Glucagon-like polypeptide). Thus, sitagliptin has been used to treat obesity and type...

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Anti-Inflammatory Agents
Cytokines
Dipeptidyl Peptidase 4
Glucagon-Like Peptide 1
Macrophage Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mannose Receptor

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PMID: 39662268
DOI: 10.1016/j.intimp.2024.113730

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