Article
Effect of gingival mesenchymal stem cell-derived exosomes on inflammatory macrophages in a high-lipid microenvironment.
International immunopharmacology - 1 May 2021
Zhang Yalong, Wang Zhiguo, Shi Bohong, Li Yan, Wang Ru, Sun Jiayao, Hu Yingzhe, Yuan Changqing, Xu Quanchen
Abstract excerpt
OBJECTIVE: The aim of this study was to examine the effect of gingival mesenchymal stem cells derived exosomes (GMSC-Exos) on lipopolysaccharide/interferon-gamma (LPS/INF-γ)-induced inflammatory macrophages in a high-lipid microenvironment. MATERIALS AND METHODS: Exosomes were obtained by culturing gingival mesenchymal stem cells (GMSCs) in alpha-MEM with exosome-free fetal bovine serum for 48 h. The control...
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