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Article

The Secretome of Preconditioned Mesenchymal Stem Cells Drives Polarization and Reprogramming of M2a Macrophages toward an IL-10-Producing Phenotype.

International journal of molecular sciences - 7 Apr 2022

Holthaus Michelle, Santhakumar Nivethiha, Wahlers Thorsten, Paunel-Görgülü Adnana

Abstract excerpt

The preconditioning of mesenchymal stem cells (MSCs) has been recognized as an attractive tool to improve their regenerative and immunomodulatory capacities based on their paracrine effects. In this study, we examined the potential of an MSC-conditioned medium (MSC-CM) to alter the phenotype of murine macrophages and to drive reprogramming toward an anti-inflammatory, M2-like state in vitro. We further explored...

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PMID: 35456922
DOI: 10.3390/ijms23084104
PMCID: PMC9024470

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