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Article

Differentiation potential of CD14+ monocytes into myofibroblasts in patients with systemic sclerosis.

PloS one - 1 Jan 2012

Binai Nadine, O'Reilly Steven, Griffiths Bridget, van Laar Jacob M, Hügle Thomas

Abstract excerpt

BACKGROUND: Circulating monocytes are a highly plastic and functionally heterogeneic cell type with an activated phenotype in patients with systemic sclerosis (SSc). CD14(+) monocytes have the potential to differentiate into extra-cellular matrix (ECM) producing cells, possibly participating in fibrogenesis. AIM: To study the effect of GM-CSF, IL-4 and endothelin -1 (ET-1) alone or in combination on monocyte...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22432031
DOI: 10.1371/journal.pone.0033508
PMCID: PMC3303833

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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