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The characteristics of extrachromosomal circular DNA in patients with end-stage renal disease

27 Mar 2023

Abstract excerpt

BACKGROUND: End-stage renal disease (ESRD) is the final stage of chronic kidney disease (CKD). In addition to the structurally intact chromosome genomic DNA, there is a double-stranded circular DNA called extrachromosomal circular DNA (eccDNA), which is thought to be involved in the epigenetic regulation of human disease. However, the features of eccDNA in ESRD patients are barely known. In this study, we...

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PMID: 36967395
DOI: 10.1186/s40001-023-01064-z

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