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Article

Predictive Analysis and Validation of Critical Missense SNPs of the ABH2 Gene Using Structural Bioinformatics.

International journal of molecular sciences - 29 Nov 2025

Davletgildeeva Anastasiia T, Tyugashev Timofey E, Sagalakova Viktoriia V, Zhao Mingxing, Kuznetsov Nikita A

Abstract excerpt

Human DNA dioxygenase ABH2 is a key enzyme of the AlkB family of Fe(II)/α-ketoglutarate-dependent oxygenases, which is specialized in removing alkyl groups from damaged DNA bases in the cell nucleus. At the same time, the occurrence of single-nucleotide polymorphisms (SNPs) in the human ABH2 gene can lead to amino acid substitutions that, in turn, may disrupt the normal functioning of the ABH2 enzyme. Currently,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41373746
DOI: 10.3390/ijms262311593
PMCID: PMC12692101

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