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Article

Molecular characterization, homology modeling and docking studies of the R2787H missense variation in BRCA2 gene: Association with breast cancer.

Journal of theoretical biology - 21 Aug 2016

Riahi Aouatef, Messaoudi Abdelmonem, Mrad Ridha, Fourati Asma, Chabouni-Bouhamed Habiba, Kharrat Maher

Abstract excerpt

The significance of many BRCA unclassified variants (UVs) has not been evaluated. Classification of these variations as neutral or pathogenic presents a significant challenge and has important implications for breast and ovarian cancer genetic counseling. Here we report a combined molecular and computational approach to classify BRCA UVs missense variations. By using the LOH (Loss of heterozygosity) analysis at...

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Share to BRCA2 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Germ-Line Mutation

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Source

Identifiers

PMID: 27211102
DOI: 10.1016/j.jtbi.2016.05.013

Genes

BRCA2
BRCA1

Provenance

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